October 03, 2022
CBD (Cannabidiol) products and the companies that distill them continue to enter the market in rapidly growing numbers. To date, the FDA has not approved a new drug marketing application (i.e NDA) for naturally cultivated cannabis used for the treatment of any disease or condition. The FDA has, however, approved one cannabis-derived (Epidiolex) and three cannabis-related drug products: Marinol, Syndros, Cesamet. These approved products are only available with a prescription from a DEA licensed healthcare provider. There are no other FDA-vetted and approved products that contain CBD. The FDA continues to be concerned at the proliferation of products asserting to contain CBD that is marketed for therapeutic or medical uses although they have not been validated by the FDA. Often such products are sold online and are therefore available throughout the country. Selling unvetted and unapproved products with unsubstantiated therapeutic claims is not only a violation of the law but also can put patients at risk, as these products have not been proven to be safe or effective. This deceptive marketing of unproven cures and treatments also raise significant public health concerns because patients and other consumers may be influenced not to use approved therapies to treat serious and even fatal diseases. (1). It is the concern of the FDA to ensure patients are kept safe and reach for only those products that are shown to be safe and efficacious for the diseases or conditions intended. As a result, there has been much discussion and debate around the testing that should be performed on CBD products for safety and efficacy as well as purity and potency. Consumer organizations and health professionals strongly urge CBD companies to perform these tests and share results as the minimum responsibility to consumers.(2) The choice of which tests and frequency of testing that are most validating remain up to the supplier-manufacturer chain of CBD products. Unfortunately, even if companies perform tests to assess purity and potency, the published results (in the form of a Certificate of Analysis- C.O.A.) are often found to not match their product claims. (3). The increasingly growing market of unapproved CBD products can result in inconsistent and frustrating (potentially unsafe) experiences for consumers seeking reliability and relief for their health ailments. Finding products that consistently perform as consumers prefer and expect is a challenge. Inconsistent experiences can vary from brand to brand, and even more alarming – within the same product line or batch. For consumers with sensitive dosing needs and especially with children, this can add more stress and anxiety while attempting to alleviate symptoms and ailments with CBD products. (4)
There are too few CBD companies performing tests for safety and efficacy in addition to purity and potency; and even fewer who are raising the bar by providing additional, transparent product testing using live cell culture. There exists the option to perform even greater pre-market rigorous testing for CBD products called Human Cell Culture Tests (i.e in-vitro), animal testing (i.e ex vivo), and ultimately randomized controlled human trials (i.e. Phase3/4). (5) The Human Cell Culture Tests specifically measure cell growth and differentiation (i.e cell viability studies) of cells treated with CBD products. This type of test is commonly used by pharmaceutical and cosmetic companies to study the efficacy of their products and determine dosages. (6) To help address the safety and efficacy issues with CBD products, CBD companies should not only perform independent third-party purity and potency testing, but also in-vitro and ex-vivo testing. These scientifically rigorous testing efforts can offer consumers the most assurance concerning safety, efficacy, purity, and cannabinoid content. Potency testing checks whether the product contains the cannabinoid content promised but it doesn’t reveal much about product safety or efficacy. Purity testing checks CBD products for the presence of “contaminants” such as microbes, heavy metals, pesticides, or residual toxins but again does not reveal safety and efficacy. The data is contained within a Certificate of Analysis (C.O.A.) that reports findings for each of these categories, broken down, and then usually summarized as a “pass” or “fail”. (7). Human Cell In-Vitro studies determine the effects of drugs, biologics and nutraceuticals (including cosmetics in some cases) upon living cells. Mett Naturals is one of the first CBD companies to perform these more rigorous studies with human cell targets using their CBD products of oil drops, creams, roll-on oil, and oil capsules. Mett Naturals engaged PhytoLife, LLC to perform human cell culture testing on all Mett Naturals CBD Products and shared 9 samples of Mett CBD products as well as 4 samples from competitor CBD companies. The Mett Naturals muscle pain creams were impractical for evaluation due to lack of solubility. Additional testing was performed on the samples in the research studies at the end of the experiments to further evaluate the effects on inflammatory pathways in their cell cultures. These additional tests evaluated inflammatory cytokines, IL-1b, IL-6, TNF-alpha and IFN-gamma. Cytokines function to regulate inflammation produced by differentiated immune cells (e.g PBMC, peripheral blood mononuclear cell). All samples were processed and evaluated via incubation and freezing processes. Then, a careful microscopic examination was performed of the cell cultures at the start and again at the termination of the experiment. These examinations revealed no bacteria contamination. In their (PhytoLife, LLC) considerable experience studying samples containing CBD, the precision of cell testing strongly indicates an interesting observation. It indicates that small differences can be detected in cell growth between different samples and different concentrations. This is of significance as high purity CBD typically shows a drop in cell growth at higher concentrations. In the Mett Naturals samples observed, the growth observed at 4ug/mL and 8ug/mL suggests that other components of their distillates, like terpenes and flavonoids contributed to additional cell growth as well as cytokine modulation. (6)
For customers seeking a more thoroughly evaluated CBD product beyond the more commonly tested purity and potency measures, Mett Naturals products should be considered. Mett Naturals is one of the first companies to perform in-vitro human cell culture tests specifically for measuring the potency (i.e dose) and efficacy (i.e response) of reducing inflammation in cells with their CBD products. The Mett Naturals Brand outperformed all competitors in side-by-side testing conducted by the 3rd party independent lab PhytoLife, LLC. Specifically, Mett Naturals roll-on line was most effective when looking at cell growth. Mett Naturals 1000mg Orange Cream and 500mg Lemonade tinctures had the greatest effect on cellular suppression of cytokine release.(6)
Consumers have more CBD product choices to choose from in the marketplace than ever before. To assist in making the best choice, consumers now have access to more resources to evaluate CBD companies’ actions to test and evaluate their CBD products. CBD companies, like Mett Naturals, choosing to test their products with “seed to cellular to shelf to consumer” research deserve a closer look by consumers.
September 16, 2022
#1 Start Low, Go Slow
It’s important to start low with your dosing to ensure you are taking the right amount for your body. If you are new to CBD or have a sensitive system, we recommend starting with 0.25ml and monitoring how you feel.
#2 Adjust your dose
CBD dosing is individualized. We suggest recording your initial dose and monitor how you feel. You may need to increase or decrease dosage from time to time to help manage stress response, sleep, or mood.* We recommend sticking with a routine for a minimum of 2 weeks before adjusting your dose.
#3 Give it time
CBD is not intoxicating, but it does have a positive impact on the body. The effects of CBD are individualized and may sometimes be subtle, so it’s important to focus on what you don’t feel, rather than what you do. Over time, you may notice that you’re sleeping better or managing stressful situations easier.
#4 Prime your body
It is important that CBD be used in conjunction with a healthy lifestyle. Being well-fed and well-hydrated sets your body up for optimal absorption. Vitamins and minerals also play an important role in optimizing CBD in the body.
Some vitamin and mineral pairings we love:
September 16, 2022
CBD, which stands for Cannabidiol, is one of the most well-known active compounds, found in hemp and cannabis plants. Mett Naturals CBD comes from the hemp plants we grow on our farm in Nyssa, Oregon. This compound (also known as a cannabinoid) works naturally with the body’s endocannabinoid system and other natural body systems to help regulate a variety of vital functions including sleep, mood, stress response and more.* CBD is not intoxicating, rather it is known to have positive impacts on the human body.
Why does CBD work so well with our bodies*?
The human body has an Endocannabinoid System (ECS) and produces its own cannabinoid compounds called Endocannabinoids.
There are endocannabinoids and endocannabinoid receptors throughout our body including the nervous system, organs, brain, and cells.* Endocannabinoids bind to the receptors to help support and protect our immune system, nervous system and virtually all organs in the body.*
The endocannabinoid receptors found throughout the body work with cannabinoids like CBD to help support the body’s natural state of balance.*
What are the effects of CBD?
When the body experiences internal or external stressors, the Endocannabinoid System is activated to help your body return to stability. Incorporating CBD into your daily routine helps boost the body’s natural creation and supply of endocannabinoids.
CBD is non-intoxicating, what this means is that you will not experience a “high”. The effects of CBD are individualized, and your Endocannabinoid System knows what your body needs at the time that you take it. If you find yourself having a hard time sleeping, CBD may make you tired, and during stressful moments, CBD may calm your mind. Because the effects can be subtle, focus on what you don’t feel rather than what you do. Overtime, you may notice you are sleeping better, or experiencing an improvement in mood.* It’s important to monitor how you’re feeling so you can better understand how much CBD is right for you.
September 20, 2021
As we make our way further into the technology age, advancements in biology and medicine grant us valuable insights into how our bodies work and how we can better care for them. While we learn more about the transmitter systems within us, we glean knowledge on how to fight and cure disease as well as how to experience a better quality of life. In recent years, scientists have discovered and began study on a transmitter system known as the Endocannabinoid System (ECS) — one that is proving to be quite vital to our well-being.
As can probably be gathered from the name, the Endocannabinoid System is interestingly related to a plant we know as Cannabis. A better understanding of this newly discovered transmitter system begins with understanding cannabis and its fundamental compounds.
Cannabis, though sometimes used synonymously with the drug marijuana, is actually a genus of plants that has been used extensively throughout history. Known for its medicinal properties as well as its applications in papermaking, cloth weaving, and yarn spinning, cannabis plants have proven to be a trusted crop in times both past and present.
Simply put, cannabinoids are specific compounds within the cannabis plant and are in number about 66— so far. When speaking about these compounds, there are two of them that have become widely recognized and well-studied. They are known as THC and CBD.
This is the compound responsible for most psychoactive effects experienced with cannabis consumption. Substances that contain concentrated amounts of THC remain criminalized at the federal level as well as in a number of states.
CBD is the second most prevalent compound in cannabis and is non-psychoactive. It does not produce any kind of high and is legal at the federal level, readily available in most parts of the United States. Research has shown that CBD can provide a number of benefits to both body and mind.
As is the case with our other transmitter systems, the ECS comprises a vast network of signals and receptors that are highly concentrated in the brain and exist throughout the body. The role of the ECS is still under study but we do know that this system helps to regulate a number of our most vital bodily functions such as:
Specialized receptors within this system known as cannabinoid receptors act as authorities over neurotransmitters or “signal senders”, essentially regulating how the brain functions. In order for these receptors to carry out their responsibilities, they recruit the help of molecules called Endocannabinoids.
These molecules produced in the body, have a structure similar to compounds within the cannabis plant. Endocannabinoids stimulate cannabinoid receptors and work to keep everything in check. In so many words, the endocannabinoids are the laborers of the operation while the cannabinoid receptors are the decision-makers, sending directives to neurotransmitters in the brain.
When the ECS becomes dysregulated, it often results in the decreased production of endocannabinoids. This deficiency is a recognized medical condition known as clinical endocannabinoid deficiency (CECD) and has been tied to a number ills including:
Reason leads many medical professionals to believe that the introduction of cannabinoids to the body may help with ECS regulation, restoring the balance that CECD fights against. Research is currently underway and looks very promising. Cannabinoids have demonstrated an ability to block spinal, peripheral, and gastrointestinal mechanisms that cause a number of conditions. In short, findings suggest that CECD may be suitably addressed with cannabinoid medicines such as those that contain CBD.
Never heard of the ECS until today? That’s okay, neither have most. The important thing is that we begin to appreciate its role in sustaining our bodies and minds. In light of what has been discovered, medical experts are beginning to explore more deeply the positive effects cannabinoid compounds such as CBD can have.
As mentioned before, CBD oils are completely safe and legal, readily available for use. If you have questions about full-spectrum CBD oil products or CBD isolates, feel free to browse our store.
September 09, 2021
Anxiety is a common condition. In many instances, anxiety can manifest temporarily in times of stress disappearing shortly after the waters calm. However, in some people, anxiety manifests as a constant burden— a persistent and excessive worry that affects everyday life. In fact, over 18 percent of the U.S population suffers from weighty anxiety disorders each year. But what if we told you humans aren’t the only ones?
Here’s a little-known fact:
Just as we are susceptible to battles with mental illness— specifically anxiety— so are our dogs and cats. Although it may seem strange, anxiety in pets is just as real and burdensome as it can be with us. To make matters worse, dogs and cats don’t often have the tools or resources to recognize, let alone cope with their condition. This causes fear within the animal and often manifests as unusual or poor behavior.
Studies show that the most common causes for anxiety in dogs and cats are cruelty, abuse, or neglect. For this reason, rescue animals are particularly prone. Another common cause is separation. Pets, specifically dogs, form strong attachments to their guardians and experience fear when left alone for long periods of time. This is why Fido can be a tad overbearing when you enter the door after a long day at work.
Regardless of the cause, it is important to recognize when your pet may have anxiety so it can be properly addressed.
Luckily, pets aren’t particularly keen on hiding their emotions— a rather endearing quality. This makes anxiety a bit easier to identify.
Dogs that are destructive or disruptive often have unaddressed anxiety. You may also notice:
Anxiety in cats manifests quite differently than in dogs. Here are some signs your cat may be experiencing anxiety:
Unfortunately, treating pet anxiety is not as simple as calling up a counselor and talking through options. However, there are prescribed medications that have been known to help. The only problem is many of these medications can cause negative side effects, complicating matters even further. Thankfully, Mett Naturals provides another solution.
CBD has proven to be ideal for natural support and the treatment of many conditions. While traditionally extracted for human consumption, CBD has been found to be completely safe for pets, providing tremendous benefits. In addition, no prescription is required for CBD, it is abundantly available, and perfectly legal at the state and federal levels.
At Mett Naturals, our pet CBD products find their origins in the flowers, leaves, and stocks of farm-grown hemp plants. Unlike hemp oil which is derived from hemp seeds and contains no CBD, CBD oil is a lab-tested, safe, and natural remedy to common ills such as anxiety. Because it contains virtually no THC, hemp-derived CBD produces no high at all— only effects that relieve.
A common rule of thumb is to administer 1 mg per 10 pounds of body weight. With time, it may be appropriate to adjust your pet’s dose to 2-3 mg per 10 pounds. CBD oil can be easily incorporated into food, or placed on top of a treat for easy consumption. The effects of CBD will last up to 8 hours.
When it comes to treating anxiety in your pets, CBD is a safe, natural remedy that can yield tremendously positive results. If you have a pet with anxiety, consider trying out our specialized pet CBD oil, extracted specifically for that purpose. If you have any additional questions or concerns, feel free to contact us at email@example.com today.
August 31, 2021
We spend roughly one-third of our lives sleeping. Sleep is as essential to our survival as food and water, helping the brain and body function properly. Interestingly enough, the biological purpose of sleep remains largely unknown, however, everyone alive needs a healthy amount of it. As it turns out, the process of sleep is quite layered and complex, opening up the opportunity for a number of related challenges.
Although we may lay our heads on a pillow and experience the passage from night to morning in an instant, there is actually a lot going on while we slumber.
Sleep is better thought of as a cycle than a constant state. According to the sleep foundation, there are four stages of sleep, the fourth being the deepest, most impactful stage. We pass through all four stages in about 90 minutes, which means a healthy night of sleep is the completion of about four to six cycles.
As soon as we enter the first stage of sleep, our bodies begin operating differently than when we are awake. Heart rate slows, hormones are released, body temperature drops, nervous impulses are dialed back, and respiration eases. At this time, the body is able to undergo a number of restorative processes including:
Unfortunately, sleep has its enemies and some of us have more disruptive run-ins than others. There are around 80 diagnosable sleep disorders, but the top offenders include:
These conditions make it difficult for individuals to either enter the sleep cycle at all or complete a full cycle without interruption.
The consequences of chronic sleep loss can impact one’s daily life and well-being in a number of ways. Studies show that lack of sleep may have wide-ranging effects including:
At the end of the day, none of the things listed above are desirable outcomes in the least. If sleep quality is an issue for you, it may be time to seek out an effective aid.
In a recent study, 72 adults presenting concerns of poor sleep or anxiety were observed and scored. After data was recorded, these adults were treated with Cannabidiol (CBD).
The results? Two-thirds of these patients improved their sleep scores within the first month of CBD use.
Research shows that CBD has a calming effect on the nervous system, making it an advocate for productive sleep. For this reason, about 10 percent of those who use CBD do so specifically to help them sleep better. Many people are beginning to gravitate towards CBD instead of prescription drugs citing adverse effects from a wide variety of pharmaceuticals. CBD is showing to be safer, easier on the body, and effective at treating a variety of sleep conditions.
Given the results of clinical trials, it is best to begin with a CBD dose of around 25-50mg, slowly increasing until results are optimal. Some individuals find smaller doses more effective, while some require slightly larger amounts.
If you are suffering from sleep loss and feel as though it is having a negative impact on your day-to-day life, CBD may be an effective solution for you. At Mett Naturals, we carry a number of quality, hemp-derived, carefully extracted CBD products that are safe and natural for the body. For more information, feel free to browse our shop.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. These products are not intended for individuals under 18 years old. Consult with a physician before use if you have a serious medical condition or use prescription medications.
Products on this site contain a value of 0% to less than 0.3% of THC.
© 2022 Mett Naturals.
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